What Neurological Conditions Can Benefit from Complement Inhibitors?
Several neurological conditions may benefit from the therapeutic use of complement inhibitors:
1. Multiple Sclerosis (MS): In MS, the immune system attacks the myelin sheath of nerve fibers, leading to inflammation and neurodegeneration. Complement inhibitors can potentially reduce this inflammatory response. 2. Neuromyelitis Optica (NMO): This condition involves severe damage to the optic nerves and spinal cord. Complement inhibitors like eculizumab have shown promise in reducing relapses. 3. Alzheimer's Disease: In Alzheimer's disease, complement activation contributes to neuronal damage and amyloid plaque formation. Complement inhibitors could help mitigate these effects. 4. Myasthenia Gravis (MG): An autoimmune disorder where antibodies attack acetylcholine receptors at the neuromuscular junction. Complement inhibitors can help reduce the severity of muscle weakness.
