What are the challenges in developing neuroprotective agents?
Developing effective neuroprotective agents poses several challenges:
- Blood-Brain Barrier (BBB): Many potential agents cannot cross the BBB, limiting their efficacy. - Complex Pathophysiology: Neurological diseases often involve multiple pathways, making it difficult for a single agent to be effective. - Clinical Trials: Demonstrating efficacy in clinical trials is challenging due to the slow progression of many neurological diseases and variability in patient populations. - Side Effects: Many neuroprotective agents can have significant side effects, limiting their use.
