Neurotransmitters are chemical messengers that transmit signals between neurons in the brain. In the context of depression, key neurotransmitters include serotonin, norepinephrine, and dopamine. Reduced levels of these neurotransmitters are often associated with depressive symptoms. Medications like selective serotonin reuptake inhibitors (SSRIs) aim to increase the availability of these neurotransmitters to alleviate symptoms.