While B cell depletion therapies can be effective, they are not without risks. Potential side effects include: - Infections: Due to the immunosuppressive nature of the treatment, patients are at an increased risk of infections. - Infusion Reactions: Some patients may experience reactions during or shortly after the infusion of the medication. - Progressive Multifocal Leukoencephalopathy (PML): Although rare, this serious brain infection has been reported in patients receiving B cell depletion therapy.